1. WHAT CIPROFLOXACIN INFUSION IS AND WHAT IT IS USED FOR Ciprofloxacin Infusion is an antibiotic belonging to the fluoroquinolone family. The active substance is ciprofloxacin. Ciprofloxacin works by killing bacteria that cause infections. It only works with specific strains of bacteria. Adults; Ciprofloxacin Infusion is used in adults to treat the following bacterial infections: • respiratory tract infections • long lasting or recurring ear or sinus infections • urinary tract infections • infections of the testicles • genital organ infections in women • gastro-intestinal tract infections and intra-abdominal infections • skin and soft tissue infections • bone and joint infections • to treat infections in patients with a very low white blood cell count (neutropenia) • to prevent infections in patients with a very low white blood cell count (neutropenia) • anthrax inhalation exposure If you have a severe infection or one that is caused by more than one type of bacterium, you may be given additional antibiotic treatment in addition to Ciprofloxacin Infusion. Children and adolescents; Ciprofloxacin Infusion is used in children and adolescents, under specialist medical supervision, to treat the following bacterial infections: • lung and bronchial infections in children and adolescents suffering from cystic fibrosis • complicated urinary tract infections, including infections that have reached the kidneys (pyelonephritis) • anthrax inhalation exposure Ciprofloxacin Infusion may also be used to treat other specific severe infections in children and adolescents when your doctor considers this necessary. 2. BEFORE YOU ARE GIVEN CIPROFLOXACIN INFUSION You must not be given Ciprofloxacin Infusion if you are: • allergic (hypersensitive) to the active substance, to other quinolone drugs or to any of the other ingredients of Ciprofloxacin Infusionwhile under treatment with Ciprofloxacin Infusion Tell your doctor immediately if any of the following occurs during treatment with Ciprofloxacin Infusion. Your doctor will decide whether treatment with Ciprofloxacin Infusion needs to be stopped. • Severe, sudden allergic reaction (an anaphylactic reaction/shock, angio-oedema). Even with the first dose, there is a rare chance that you may experience a severe allergic reaction with the following symptoms: tightness in the chest, feeling dizzness and swelling in the joints, and tendinitis may occur occasionally, particularly if you are elderly and are also being treated with corticosteroids. At the first sign of any pain or inflammation Ciprofloxacin Infusion will have to be stopped. Rest the painful area. Avoid any unnecessary exercise as this might increase the risk of a tendon rupture. • If you suffer from epilepsy or other neurological conditions such as cerebral ischemia or stroke, you may experience side effects associated with the central nervous system. If this happens, stop taking Ciprofloxacin Infusion and contact your doctor immediately. • You may experience psychiatric reactions after first administration of ciprofloxacin. If you suffer from depression or psychosis, your symptoms may become worse under treatment with Ciprofloxacin Infusion. If this happens, stop taking Ciprofloxacin Infusion and contact your doctor immediately. • You may experience symptoms of neuropathy such as pain, burning, tingling, numbness and/or weakness. If this happens, stop taking Ciprofloxacin Infusion and contact your doctor immediately. • Diarrhoea may develop while you are on antibiotics, including Ciprofloxacin Infusion or even several weeks after you have stopped using them. If it becomes severe or persistent or you notice that your stool contains blood or mucus, tell your doctor immediately. Ciprofloxacin Infusion treatment will have to be stopped immediately, as this can be life-threatening. Do not take medicines that stop or slow down bowel movements. • Tell the doctor or laboratory staff that you are taking Ciprofloxacin Infusion if you have to provide a blood or urine sample. • Ciprofloxacin Infusion may cause liver damage. If you notice any symptoms such as loss of appetite, jaundice (yellowing of the skin), dark urine, itching, or tenderness of the stomach, Ciprofloxacin Infusion must be stopped immediately. • Ciprofloxacin Infusion may cause a reduction in the number of white blood cells and your resistance to infection may be decreased. If you experience an infection with symptoms such as fever and serious deterioration of your general condition, or fever with local infection symptoms such as sore throat/pharynx/mouth or urinary problems you should see your doctor immediately. A blood test will be taken to check possible reduction of white blood cells (agranulocytosis). It is important to inform your doctor about your medicine. • Tell your doctor if you or a member of your family is known to have a deficiency in glucose-6-phosphate dehydrogenase (G6PD), since you may experience a risk of anaemia with ciprofloxacin. • Your skin becomes more sensitive to sunlight or ultraviolet (UV) light under treatment with Ciprofloxacin Infusion. Avoid exposure to strong sunlight or artificial UV light such as sunbeds. • If your eyesight becomes impaired or if your eyes seem to be otherwise affected, consult an eye specialist immediately. Taking other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other
